Last edited by Vugrel
Friday, July 31, 2020 | History

5 edition of Solubility and solubilization in aqueous media found in the catalog.

Solubility and solubilization in aqueous media

by Samuel H. Yalkowsky

  • 86 Want to read
  • 8 Currently reading

Published by American Chemical Society, Oxford University Press in Washington, D.C, New York .
Written in English

    Subjects:
  • Organic compounds -- Solubility.,
  • Solution (Chemistry)

  • Edition Notes

    Includes bibliographical references and index.

    StatementSamuel H. Yalkowsky.
    Classifications
    LC ClassificationsQD255.4 .Y26 1999
    The Physical Object
    Paginationxvi, 464 p. :
    Number of Pages464
    ID Numbers
    Open LibraryOL389199M
    ISBN 100841235767
    LC Control Number98053282

    Solubilization of Drugs in Aqueous Media. With Paul B Myrdal, Samuel H Yalkowsky. In order to obtain a solution formulation for drugs with poor solubility, it is necessary to alter the formulation to facilitate solubilization. This entry is designed to summarize the theoretical as well as practical use of each solubilization technique. The successful exfoliation of graphite to graphene sheets in a liquid phase via tip sonication was achieved. A number of solvents were examined for several time periods and it was found that o-dichlorobenzene (o-DCB) and N-methyl-1,2-pyrolidone (NMP) .

    New molecules and even existing drugs suffer considerably from low solubility in aqueous media and thereby demonstrate low oral bioavailability. As the passage through the gastrointestinal tract offers only a short duration of time, the rate at which the solid-state drug goes into aqueous solution is extremely critical for good bioavailability. formulations. Most of drugs weakly acidic and weakly basic with poor aqueous solubility. Hence various techniques are used for the improvement of the solubility of poorly water-soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, complexation, co‐solvency, micellar solubilization, hydrotropy etc.

    Start Page:: ill. ; 25 cm. Publisher: American Chemical Society ISBN: All titles: " Solubility and solubilization in aqueous media ". The increasing popularity of porphyrins and hydroporphyrins for use in a variety of biomedical (photodynamic therapy, fluorescence tagging and imaging, photoacoustic imaging) and technical (chemosensing, catalysis, light harvesting) applications is also associated with the growing number of methodologies that enable their solubilization in aqueous media. Natively, the vast majority of.


Share this book
You might also like
Rural development in action

Rural development in action

Rural China

Rural China

Guide to college reading

Guide to college reading

Workplace Goods Job Growth and Competitiveness Act of 1999

Workplace Goods Job Growth and Competitiveness Act of 1999

Oedipus tyrannus

Oedipus tyrannus

Words and phrases legally defined.

Words and phrases legally defined.

English-Swedish dictionary. School ed

English-Swedish dictionary. School ed

The yo-yo syndrome diet

The yo-yo syndrome diet

World communities. Teachers manual

World communities. Teachers manual

Energy Efficient Hospitals

Energy Efficient Hospitals

Solubility and solubilization in aqueous media by Samuel H. Yalkowsky Download PDF EPUB FB2

The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media. It discusses in detail the most commonly used solubility enhancers: buffers, cosolvents, surfactants, and by: This book aims to provide the reader with a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium.

The book begins with the factors which govern solubility in general and then looks at aqueous solubility in particular, including the properties of liquid mixtures 4/5(2). The bulk of the book is then devoted to Solubility and solubilization in aqueous media book for altering solubility and dissolution rate of organic compounds in aqueous media.

It discusses in detail the most commonly used solubility enhancers: buffers, co-solvents, surfactants, and complexants. Each chapter is self-contained and emphasizes the details for applying the techniques. show 4/5(1).

Solubility and Solubilization in Aqueous Media By Samuel H. Yalkowsky (University of Arizona). Oxford University Press: New York. xvi + pp. $ ISBN 0 Cited by: 4. Solubility and Solubilization in Aqueous Media Samuel H. Yalkowsky. American Chemical Society. ACS Professional Reference Book.

This book gives chemists methods for controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium.

The aim of this book is to provide the reader with a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium. While solubility and solubilization will be aprroached from both a conceptual and a practical point of view, emphasis will be placed on the latter.

Booktopia has Solubility and Solubilization in Aqueous Media, American Chemical Society Publication by Samuel H. Yalkowsky. Buy a discounted Hardcover of Solubility and Solubilization in Aqueous Media online from Australia's leading online : Hardcover. The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media.

It discusses in detail the most commonly used solubility enhancers: buffers, co-solvents, surfactants, and complexants. Each chapter is self-contained and emphasizes the details for applying the techniques. scientific publications, four patents, and four books. His most recent book Solubility and Solubilization in Aqueous Media, ACS-Oxford, was published in Dr.

Yalkowsky co-authored two papers that won the Ebert Prize for the best scientific paper in the Journal of Pharmaceutical Sciences.

He received the University of Arizona Graduate. Pharmacosome-type complexes can increase drug solubility in both aqueous and non-aqueous media, as well as drug bioavailability after oral administration of the solid complex (Li et al.,Semalty et al.,Singh et al.,Xia et al., ).

Although the drug solubility in aqueous solutions is frequently only slightly improved upon. In the context of solubility and solubilization, complexation can best be studied using the phase solubility methods described by Higuchi and Connors, 56 and by Repta.

55 Based on the phase solubility diagram, i.e., dependence of solubility on ligand concentration, Higuchi and Connors suggested classifying complexation phenomena/complexes into. Solubility and solubilization in aqueous media by Samuel H. Yalkowsky,American Chemical Society, Oxford University Press edition, in EnglishPages:   Solubilization 1.

SOLUBILIZATION & METHOD OF SOLUBILIZATION) 2. SOLUBILITY It can be defined quantitatively as the conc. of solute in a saturated solution at a certain temperature, and qualitatively as the spontaneous interaction of two or more substances to form a homogenous molecular dispersion It can also be defined as the molecular dispersion of solute in the solvent.

Importance of. Get this from a library. Solubility and solubilization in aqueous media. [Samuel H Yalkowsky] -- "Written for both new and experienced researchers in pharmaceuticals, this book gives the reader a working knowledge of the various means of controlling the solubility and dissolution rates of drugs.

The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media. It discusses in detail the most commonly used solubility enhancers: buffers, cosolvents, surfactants, and complexants.

Each chapter is self-contained and emphasizes the details for applying the : $   Surfactants had a noticeable effect in increasing CsA solubility. Twenty percent solutions of Tw Tw and Cremophor EL increased the solubility by 60 to fold.

Solubility and Solubilization in Aqueous Media. New York, NY: Oxford University Press; 5. Yalkowsky SH, Roseman TJ. Techniques of Solubilization of Drugs. S cocrystal,T represents the sum of cocrystal solubilities in aqueous and micellar environments, S cocrystal,T = S cocrystal,aq + S cocrystal,mic.K sp is the cocrystal solubility product, K sp = (S cocrystal,aq) 2.K s stands for solubilization constants of cocrystal constituents, and the term in brackets is the concentration of solubilizing agent, which for a micellar surfactant is [M].

This study investigated the solubilization of cyclosporin A (CsA), a neutral undecapeptide, by cosolvency, micellization, and complexation. Cosolvents (ethanol, propylene glycol, polyethylene glycol, tetrahydrofurfuryl alcohol polyethyleneglycol ether, and glycerin), surfactants (polyoxyethylene sorbitan monooleate [(Tween 80)], polyoxyethylene sorbitan monolaurate [(Tween 20)], and Cremophor.

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response.

Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Solubility and Solubilization in Aqueous Media (American Chemical Society Publication) by Samuel H.

Yalkowsky () Hardcover – out of 5 stars 1 rating See all 4 formats and editions Hide other formats and editionsReviews: 1. • Co-Solvents can increase the solubility of poorly soluble compounds several thousand times compared to the aqueous solubility of the drug alone. • Very high drug concentrations of poorly soluble compounds can be dissolved compared to other solubilization approaches.

Handbook of Aqueous Solubility Data download book. Handbook of Aqueous Solubility Data download pdf rapidshare mediafire fileserve, 4shared torrent ebook,kindle,online book,download book,epub,fb2,djvu,torrent,nook,free.

Ebook Solubility and Solubilization in Aqueous Media (American Chemical Society Publication) Free. nENCY. In: Solubility and Solubilization in Aqueous Media. New York, NY: Oxford University Press; Surfactant Systems: their Chemistry, Pharmacy and Biology.